| EC NUMBER | COMMON NAME | ORPHAN | Swiss-Prot | TrEMBL |
| EC 1.1.1.1 | Alcohol dehydrogenase | - | 228 | 2319 |
| EC 1.1.2.2 | Mannitol dehydrogenase (cytochrome) | - | - | 3 |
| EC 1.1.3.3 | Malate oxidase | Yes | - | - |
| EC 1.1.4.1 | Vitamin-K-epoxide reductase (warfarin-sensitive) | - | 4 | 3 |
| EC 1.1.5.2 | Quinoprotein glucose dehydrogenase | - | 4 | 187 |
| EC 1.1.99.1 | Choline dehydrogenase | - | 121 | 465 |
| EC 1.2.1.2 | Formate dehydrogenase | - | 33 | 1554 |
| EC 1.2.2.1 | Formate dehydrogenase (cytochrome) | - | - | 35 |
| EC 1.2.3.1 | Aldehyde oxidase | - | 13 | 24 |
| EC 1.2.4.1 | Pyruvate dehydrogenase (acetyl-transferring) | - | 103 | 1589 |
| EC 1.2.7.1 | Pyruvate synthase | - | 27 | 459 |
| EC 1.2.99.2 | Carbon-monoxide dehydrogenase (acceptor) | - | 34 | 492 |
| EC 1.3.1.1 | Dihydrouracil dehydrogenase (NAD(+)) | - | - | 49 |
| EC 1.3.2.3 | L-galactonolactone dehydrogenase | - | 4 | 16 |
| EC 1.3.3.1 | Dihydroorotate oxidase | - | 132 | 869 |
| EC 1.3.5.1 | Succinate dehydrogenase (ubiquinone) | - | 48 | 865 |
| EC 1.3.7.1 | 6-hydroxynicotinate reductase | - | - | 5 |
| EC 1.3.99.1 | Succinate dehydrogenase | - | 44 | 2110 |
| EC 1.4.1.1 | Alanine dehydrogenase | - | 27 | 523 |
| EC 1.4.2.1 | Glycine dehydrogenase (cytochrome) | Yes | - | - |
| EC 1.4.3.1 | D-aspartate oxidase | - | 8 | 19 |
| EC 1.4.4.2 | Glycine dehydrogenase (decarboxylating) | - | 536 | 771 |
| EC 1.4.7.1 | Glutamate synthase (ferredoxin) | - | 11 | 304 |
| EC 1.4.99.1 | D-amino-acid dehydrogenase | - | 169 | 473 |
| EC 1.5.1.1 | Pyrroline-2-carboxylate reductase | - | - | 1 |
| EC 1.5.3.1 | Sarcosine oxidase | - | 20 | 477 |
| EC 1.5.4.1 | Pyrimidodiazepine synthase | - | - | 5 |
| EC 1.5.5.1 | Electron-transferring-flavoprotein dehydrogenase | - | 13 | 378 |
| EC 1.5.7.1 | Methylenetetrahydrofolate reductase (ferredoxin) | Yes | - | - |
| EC 1.5.8.1 | Dimethylamine dehydrogenase | - | 1 | - |
| EC 1.5.99.1 | Sarcosine dehydrogenase | - | 3 | 24 |
| EC 1.6.1.1 | NAD(P)(+) transhydrogenase (B-specific) | - | 94 | 383 |
| EC 1.6.2.2 | Cytochrome-b5 reductase | - | 86 | 57 |
| EC 1.6.3.1 | NAD(P)H oxidase | - | 9 | 35 |
| EC 1.6.5.2 | NAD(P)H dehydrogenase (quinone) | - | 10 | 200 |
| EC 1.6.6.9 | Trimethylamine-N-oxide reductase | - | - | 63 |
| EC 1.6.99.1 | NADPH dehydrogenase | - | 39 | 103 |
| EC 1.7.1.1 | Nitrate reductase (NADH) | - | 24 | 191 |
| EC 1.7.2.1 | Nitrite reductase (NO-forming) | - | 15 | 149 |
| EC 1.7.3.1 | Nitroalkane oxidase | Yes | - | - |
| EC 1.7.7.1 | Ferredoxin--nitrite reductase | - | 8 | 151 |
| EC 1.7.99.1 | Hydroxylamine reductase | - | 4 | 23 |
| EC 1.8.1.2 | Sulfite reductase (NADPH) | - | 239 | 448 |
| EC 1.8.2.1 | Sulfite dehydrogenase | - | - | 48 |
| EC 1.8.3.1 | Sulfite oxidase | - | 7 | 32 |
| EC 1.8.4.1 | Glutathione--homocystine transhydrogenase | - | - | 3 |
| EC 1.8.5.1 | Glutathione dehydrogenase (ascorbate) | - | - | 16 |
| EC 1.8.7.1 | Sulfite reductase (ferredoxin) | - | 6 | 115 |
| EC 1.8.98.1 | CoB--CoM heterodisulfide reductase | - | 28 | 219 |
| EC 1.8.99.1 | Sulfite reductase | - | - | 8 |
| EC 1.9.3.1 | Cytochrome-c oxidase | - | 543 | 106128 |
| EC 1.9.6.1 | Nitrate reductase (cytochrome) | - | - | 4 |
| EC 1.9.99.1 | Iron--cytochrome-c reductase | Yes | - | - |
| EC 1.10.1.1 | Trans-acenaphthene-1,2-diol dehydrogenase | Yes | - | - |
| EC 1.10.2.1 | L-ascorbate--cytochrome-b5 reductase | Yes | - | - |
| EC 1.10.3.1 | Catechol oxidase | - | 15 | 43 |
| EC 1.10.99.1 | Plastoquinol--plastocyanin reductase | - | 55 | 108 |
| EC 1.11.1.1 | NADH peroxidase | - | 1 | 45 |
| EC 1.12.1.2 | Hydrogen dehydrogenase | - | 8 | 46 |
| EC 1.12.2.1 | Cytochrome-c3 hydrogenase | - | 12 | 45 |
| EC 1.12.5.1 | Hydrogen:quinone oxidoreductase | - | 2 | 100 |
| EC 1.12.7.2 | Ferredoxin hydrogenase | - | 5 | 202 |
| EC 1.12.98.1 | Coenzyme F420 hydrogenase | - | 12 | 95 |
| EC 1.12.99.6 | Hydrogenase (acceptor) | - | 35 | 335 |
| EC 1.13.11.1 | Catechol 1,2-dioxygenase | - | 9 | 161 |
| EC 1.13.12.1 | Arginine 2-monooxygenase | Yes | - | - |
| EC 1.13.99.1 | Inositol oxygenase | - | 13 | 21 |
| EC 1.14.11.1 | Gamma-butyrobetaine dioxygenase | - | 7 | 56 |
| EC 1.14.12.1 | Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) | - | - | 20 |
| EC 1.14.13.1 | Salicylate 1-monooxygenase | - | 2 | 122 |
| EC 1.14.14.1 | Unspecific monooxygenase | - | 236 | 339 |
| EC 1.14.15.1 | Camphor 5-monooxygenase | - | 1 | 11 |
| EC 1.14.16.1 | Phenylalanine 4-monooxygenase | - | 13 | 198 |
| EC 1.14.17.1 | Dopamine beta-monooxygenase | - | 6 | 8 |
| EC 1.14.18.1 | Monophenol monooxygenase | - | 30 | 128 |
| EC 1.14.19.1 | Stearoyl-CoA 9-desaturase | - | 16 | 199 |
| EC 1.14.20.1 | Deacetoxycephalosporin-C synthase | - | 3 | - |
| EC 1.14.21.1 | (S)-stylopine synthase | - | - | 1 |
| EC 1.14.99.1 | Prostaglandin-endoperoxide synthase | - | 16 | 23 |
| EC 1.15.1.1 | Superoxide dismutase | - | 420 | 4695 |
| EC 1.16.1.1 | Mercury(II) reductase | - | 13 | 161 |
| EC 1.16.3.1 | Ferroxidase | - | 83 | 223 |
| EC 1.16.8.1 | Cob(II)yrinic acid a,c-diamide reductase | - | 1 | 119 |
| EC 1.17.1.1 | CDP-4-dehydro-6-deoxyglucose reductase | Yes | - | - |
| EC 1.17.3.1 | Pteridine oxidase | Yes | - | - |
| EC 1.17.4.1 | Ribonucleoside-diphosphate reductase | - | 162 | 3783 |
| EC 1.17.5.1 | Phenylacetyl-CoA dehydrogenase | Yes | - | - |
| EC 1.17.7.1 | (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase | - | 438 | 224 |
| EC 1.17.99.1 | 4-cresol dehydrogenase (hydroxylating) | - | 1 | 12 |
| EC 1.18.1.1 | Rubredoxin--NAD(+) reductase | - | 2 | 28 |
| EC 1.18.6.1 | Nitrogenase | - | 188 | 1515 |
| EC 1.19.6.1 | Nitrogenase (flavodoxin) | - | - | 7 |
| EC 1.20.1.1 | Phosphonate dehydrogenase | - | 1 | 8 |
| EC 1.20.4.1 | Arsenate reductase (glutaredoxin) | - | 11 | 515 |
| EC 1.20.98.1 | Arsenate reductase (azurin) | - | 4 | 26 |
| EC 1.20.99.1 | Arsenate reductase (donor) | - | - | 4 |
| EC 1.21.3.1 | Isopenicillin-N synthase | - | 11 | 5 |
| EC 1.21.4.1 | D-proline reductase (dithiol) | - | 2 | 52 |
| EC 1.21.99.1 | Beta-cyclopiazonate dehydrogenase | Yes | - | - |
| EC 1.97.1.1 | Chlorate reductase | - | 4 | - |
| EC 2.1.1.1 | Nicotinamide N-methyltransferase | - | 16 | 11 |
| EC 2.1.2.1 | Glycine hydroxymethyltransferase | - | 822 | 1799 |
| EC 2.1.3.1 | Methylmalonyl-CoA carboxytransferase | - | 3 | 31 |
| EC 2.1.4.1 | Glycine amidinotransferase | - | 7 | 17 |
| EC 2.2.1.1 | Transketolase | - | 77 | 1396 |
| EC 2.3.1.1 | Amino-acid N-acetyltransferase | - | 237 | 784 |
| EC 2.3.2.1 | D-glutamyltransferase | - | - | 1 |
| EC 2.3.3.1 | Citrate (Si)-synthase | - | 107 | 1590 |
| EC 2.4.1.1 | Phosphorylase | - | 45 | 1694 |
| EC 2.4.2.1 | Purine-nucleoside phosphorylase | - | 214 | 774 |
| EC 2.4.99.1 | Beta-galactoside alpha-2,6-sialyltransferase | - | 14 | 9 |
| EC 2.5.1.1 | Dimethylallyltranstransferase | - | 53 | 242 |
| EC 2.6.1.1 | Aspartate transaminase | - | 79 | 1866 |
| EC 2.6.3.1 | Oximinotransferase | Yes | - | - |
| EC 2.6.99.1 | dATP(dGTP)--DNA purinetransferase | Yes | - | - |
| EC 2.7.1.1 | Hexokinase | - | 52 | 105 |
| EC 2.7.2.1 | Acetate kinase | - | 335 | 789 |
| EC 2.7.3.1 | Guanidinoacetate kinase | - | 1 | - |
| EC 2.7.4.1 | Polyphosphate kinase | - | 86 | 1991 |
| EC 2.7.6.1 | Ribose-phosphate diphosphokinase | - | 200 | 2289 |
| EC 2.7.7.1 | Nicotinamide-nucleotide adenylyltransferase | - | 58 | 158 |
| EC 2.7.8.1 | Ethanolaminephosphotransferase | - | 11 | 35 |
| EC 2.7.9.1 | Pyruvate, phosphate dikinase | - | 20 | 469 |
| EC 2.7.10.1 | Receptor protein-tyrosine kinase | - | 303 | 610 |
| EC 2.7.11.1 | Non-specific serine/threonine protein kinase | - | 1966 | 1946 |
| EC 2.7.12.1 | Dual-specificity kinase | - | 73 | 72 |
| EC 2.7.13.1 | Protein-histidine pros-kinase | - | - | 8 |
| EC 2.7.99.1 | Triphosphate--protein phosphotransferase | Yes | - | - |
| EC 2.8.1.1 | Thiosulfate sulfurtransferase | - | 140 | 393 |
| EC 2.8.2.1 | Aryl sulfotransferase | - | 9 | 3 |
| EC 2.8.3.1 | Propionate CoA-transferase | - | - | 69 |
| EC 2.8.4.1 | Coenzyme-B sulfoethylthiotransferase | - | 36 | 157 |
| EC 2.9.1.1 | L-seryl-tRNA(Sec) selenium transferase | - | 127 | 291 |
| EC 3.1.1.1 | Carboxylesterase | - | 168 | 783 |
| EC 3.1.2.1 | Acetyl-CoA hydrolase | - | 13 | 139 |
| EC 3.1.3.1 | Alkaline phosphatase | - | 30 | 1062 |
| EC 3.1.4.1 | Phosphodiesterase I | - | 10 | 61 |
| EC 3.1.5.1 | dGTPase | - | 54 | 271 |
| EC 3.1.6.1 | Arylsulfatase | - | 11 | 217 |
| EC 3.1.7.1 | Prenyl-diphosphatase | Yes | - | - |
| EC 3.1.8.1 | Aryldialkylphosphatase | - | 15 | 32 |
| EC 3.1.11.1 | Exodeoxyribonuclease I | - | 6 | 334 |
| EC 3.1.13.1 | Exoribonuclease II | - | 92 | 522 |
| EC 3.1.15.1 | Venom exonuclease | - | - | 1 |
| EC 3.1.16.1 | Spleen exonuclease | Yes | - | - |
| EC 3.1.21.1 | Deoxyribonuclease I | - | 16 | 230 |
| EC 3.1.22.1 | Deoxyribonuclease II | - | 10 | 10 |
| EC 3.1.25.1 | Deoxyribonuclease (pyrimidine dimer) | - | 1 | 11 |
| EC 3.1.26.1 | Physarum polycephalum ribonuclease | Yes | - | - |
| EC 3.1.27.1 | Ribonuclease T(2) | - | 37 | 127 |
| EC 3.1.30.1 | Aspergillus nuclease S(1) | - | 2 | 19 |
| EC 3.1.31.1 | Micrococcal nuclease | - | 10 | 104 |
| EC 3.2.1.1 | Alpha-amylase | - | 123 | 603 |
| EC 3.2.2.1 | Purine nucleosidase | - | - | 220 |
| EC 3.3.1.1 | Adenosylhomocysteinase | - | 247 | 967 |
| EC 3.3.2.1 | Isochorismatase | - | 9 | 311 |
| EC 3.4.11.1 | Leucyl aminopeptidase | - | 433 | 772 |
| EC 3.4.13.3 | Xaa-His dipeptidase | - | 7 | 449 |
| EC 3.4.14.1 | Dipeptidyl-peptidase I | - | 7 | 22 |
| EC 3.4.15.1 | Peptidyl-dipeptidase A | - | 12 | 55 |
| EC 3.4.16.2 | Lysosomal Pro-Xaa carboxypeptidase | - | 4 | 25 |
| EC 3.4.17.1 | Carboxypeptidase A | - | 13 | 57 |
| EC 3.4.18.1 | Cathepsin X | - | 4 | - |
| EC 3.4.19.1 | Acylaminoacyl-peptidase | - | 7 | 78 |
| EC 3.4.21.1 | Chymotrypsin | - | 19 | 42 |
| EC 3.4.22.1 | Cathepsin B | - | 11 | 42 |
| EC 3.4.23.1 | Pepsin A | - | 19 | 60 |
| EC 3.4.24.1 | Atrolysin A | - | 1 | - |
| EC 3.4.25.1 | Proteasome endopeptidase complex | - | 312 | 2395 |
| EC 3.5.1.1 | Asparaginase | - | 39 | 946 |
| EC 3.5.2.1 | Barbiturase | - | 1 | 10 |
| EC 3.5.3.1 | Arginase | - | 40 | 223 |
| EC 3.5.4.1 | Cytosine deaminase | - | 4 | 363 |
| EC 3.5.5.1 | Nitrilase | - | 11 | 156 |
| EC 3.5.99.1 | Riboflavinase | - | - | 1 |
| EC 3.6.1.1 | Inorganic diphosphatase | - | 315 | 1638 |
| EC 3.6.2.1 | Adenylylsulfatase | Yes | - | - |
| EC 3.6.3.1 | Phospholipid-translocating ATPase | - | 52 | 146 |
| EC 3.6.4.1 | Myosin ATPase | - | - | 15 |
| EC 3.6.5.1 | Heterotrimeric G-protein GTPase | - | - | 14 |
| EC 3.7.1.1 | Oxaloacetase | - | 1 | 2 |
| EC 3.8.1.1 | Alkylhalidase | - | - | 15 |
| EC 3.9.1.1 | Phosphoamidase | Yes | - | - |
| EC 3.10.1.1 | N-sulfoglucosamine sulfohydrolase | - | 1 | 10 |
| EC 3.11.1.1 | Phosphonoacetaldehyde hydrolase | - | 67 | 74 |
| EC 3.12.1.1 | Trithionate hydrolase | Yes | - | - |
| EC 3.13.1.1 | UDP-sulfoquinovose synthase | - | 2 | 58 |
| EC 4.1.1.1 | Pyruvate decarboxylase | - | 32 | 59 |
| EC 4.1.2.2 | Ketotetrose-phosphate aldolase | - | - | 1 |
| EC 4.1.3.1 | Isocitrate lyase | - | 46 | 413 |
| EC 4.1.99.1 | Tryptophanase | - | 56 | 131 |
| EC 4.2.1.1 | Carbonate dehydratase | - | 106 | 2330 |
| EC 4.2.2.1 | Hyaluronate lyase | - | 4 | 46 |
| EC 4.2.3.1 | Threonine synthase | - | 25 | 1077 |
| EC 4.2.99.12 | Carboxymethyloxysuccinate lyase | Yes | - | - |
| EC 4.3.1.1 | Aspartate ammonia-lyase | - | 12 | 405 |
| EC 4.3.2.1 | Argininosuccinate lyase | - | 617 | 577 |
| EC 4.3.3.1 | 3-ketovalidoxylamine C-N-lyase | Yes | - | - |
| EC 4.3.99.2 | Carboxybiotin decarboxylase | Yes | - | - |
| EC 4.4.1.1 | Cystathionine gamma-lyase | - | 11 | 209 |
| EC 4.5.1.1 | DDT-dehydrochlorinase | Yes | - | - |
| EC 4.6.1.1 | Adenylate cyclase | - | 86 | 905 |
| EC 4.99.1.1 | Ferrochelatase | - | 429 | 1192 |
| EC 5.1.1.1 | Alanine racemase | - | 363 | 2310 |
| EC 5.1.2.1 | Lactate racemase | Yes | - | - |
| EC 5.1.3.1 | Ribulose-phosphate 3-epimerase | - | 41 | 1251 |
| EC 5.1.99.1 | Methylmalonyl-CoA epimerase | - | 4 | 182 |
| EC 5.2.1.1 | Maleate isomerase | - | - | 21 |
| EC 5.3.1.1 | Triose-phosphate isomerase | - | 654 | 2260 |
| EC 5.3.2.1 | Phenylpyruvate tautomerase | - | 16 | 6 |
| EC 5.3.3.1 | Steroid Delta-isomerase | - | 23 | 24 |
| EC 5.3.4.1 | Protein disulfide-isomerase | - | 68 | 374 |
| EC 5.3.99.2 | Prostaglandin-D synthase | - | 17 | 1 |
| EC 5.4.1.1 | Lysolecithin acylmutase | Yes | - | - |
| EC 5.4.2.1 | Phosphoglycerate mutase | - | 840 | 1822 |
| EC 5.4.3.2 | Lysine 2,3-aminomutase | - | 2 | 347 |
| EC 5.4.4.1 | (Hydroxyamino)benzene mutase | Yes | - | - |
| EC 5.4.99.1 | Methylaspartate mutase | - | 15 | 69 |
| EC 5.5.1.1 | Muconate cycloisomerase | - | 6 | 136 |
| EC 5.99.1.1 | Thiocyanate isomerase | Yes | - | - |
| EC 6.1.1.1 | Tyrosine--tRNA ligase | - | 544 | 956 |
| EC 6.2.1.1 | Acetate--CoA ligase | - | 200 | 864 |
| EC 6.3.1.1 | Aspartate--ammonia ligase | - | 151 | 271 |
| EC 6.3.2.1 | Pantoate--beta-alanine ligase | - | 563 | 520 |
| EC 6.3.3.1 | Phosphoribosylformylglycinamidine cyclo-ligase | - | 486 | 1392 |
| EC 6.3.4.1 | GMP synthase | - | - | 8 |
| EC 6.3.5.1 | NAD(+) synthase (glutamine-hydrolyzing) | - | 20 | 491 |
| EC 6.4.1.1 | Pyruvate carboxylase | - | 19 | 334 |
| EC 6.5.1.1 | DNA ligase (ATP) | - | 174 | 706 |
| EC 6.6.1.1 | Magnesium chelatase | - | 38 | 373 |
| EC 1.1.1.2 | Alcohol dehydrogenase (NADP(+)) | - | 24 | 132 |
| EC 1.1.2.3 | L-lactate dehydrogenase (cytochrome) | - | 114 | 318 |
| EC 1.1.3.4 | Glucose oxidase | - | 3 | 15 |
| EC 1.1.4.2 | Vitamin-K-epoxide reductase (warfarin-insensitive) | Yes | - | - |
| EC 1.1.5.3 | Glycerol-3-phosphate dehydrogenase | - | 116 | 246 |
| EC 1.1.99.2 | 2-hydroxyglutarate dehydrogenase | - | 8 | 33 |
| EC 1.2.1.3 | Aldehyde dehydrogenase (NAD(+)) | - | 105 | 959 |
| EC 1.2.2.2 | Pyruvate dehydrogenase (cytochrome) | - | 1 | 215 |
| EC 1.2.3.3 | Pyruvate oxidase | - | 2 | 115 |
| EC 1.2.4.2 | Oxoglutarate dehydrogenase (succinyl-transferring) | - | 94 | 703 |
| EC 1.2.7.2 | 2-oxobutyrate synthase | Yes | - | - |
| EC 1.2.99.3 | Aldehyde dehydrogenase (pyrroloquinoline-quinone) | - | 4 | 116 |
| EC 1.3.1.2 | Dihydropyrimidine dehydrogenase (NADP(+)) | - | 10 | 73 |
| EC 1.3.3.3 | Coproporphyrinogen oxidase | - | 239 | 557 |
| EC 1.3.5.2 | Dihydroorotate dehydrogenase | - | 391 | 2 |
| EC 1.3.7.2 | 15,16-dihydrobiliverdin:ferredoxin oxidoreductase | - | 19 | 3 |
| EC 1.3.99.2 | Butyryl-CoA dehydrogenase | - | 8 | 385 |
| EC 1.4.1.2 | Glutamate dehydrogenase | - | 21 | 276 |
| EC 1.4.3.2 | L-amino-acid oxidase | - | 31 | 32 |
| EC 1.4.99.2 | Taurine dehydrogenase | - | - | 5 |
| EC 1.5.1.2 | Pyrroline-5-carboxylate reductase | - | 59 | 1567 |
| EC 1.5.3.2 | N-methyl-L-amino-acid oxidase | - | - | 29 |
| EC 1.5.8.2 | Trimethylamine dehydrogenase | - | 1 | 15 |
| EC 1.5.99.2 | Dimethylglycine dehydrogenase | - | 3 | 42 |
| EC 1.6.1.2 | NAD(P)(+) transhydrogenase (AB-specific) | - | 18 | 840 |
| EC 1.6.2.4 | NADPH--hemoprotein reductase | - | 22 | 93 |
| EC 1.6.5.3 | NADH dehydrogenase (ubiquinone) | - | 1372 | 57016 |
| EC 1.6.99.3 | NADH dehydrogenase | - | 131 | 1108 |
| EC 1.7.1.2 | Nitrate reductase (NAD(P)H) | - | 3 | 13 |
| EC 1.7.2.2 | Nitrite reductase (cytochrome; ammonia-forming) | - | 77 | 303 |
| EC 1.7.3.2 | Acetylindoxyl oxidase | Yes | - | - |
| EC 1.7.7.2 | Ferredoxin--nitrate reductase | - | - | 16 |
| EC 1.7.99.4 | Nitrate reductase | - | 159 | 1568 |
| EC 1.8.1.3 | Hypotaurine dehydrogenase | - | - | 1 |
| EC 1.8.2.2 | Thiosulfate dehydrogenase | - | - | 4 |
| EC 1.8.3.2 | Thiol oxidase | - | 27 | - |
| EC 1.8.4.2 | Protein-disulfide reductase (glutathione) | - | 4 | 7 |
| EC 1.8.5.2 | Thiosulfate dehydrogenase (quinone) | Yes | - | - |
| EC 1.8.98.2 | Sulfiredoxin | - | 5 | 4 |
| EC 1.8.99.2 | Adenylyl-sulfate reductase | - | - | 59 |
| EC 1.10.2.2 | Ubiquinol--cytochrome-c reductase | - | 39 | 1038 |
| EC 1.10.3.2 | Laccase | - | 76 | 937 |
| EC 1.10.99.2 | Ribosyldihydronicotinamide dehydrogenase (quinone) | - | 4 | 28 |
| EC 1.11.1.2 | NADPH peroxidase | Yes | - | - |
| EC 1.12.1.3 | Hydrogen dehydrogenase (NADP(+)) | Yes | - | - |
| EC 1.12.98.2 | 5,10-methenyltetrahydromethanopterin hydrogenase | - | 13 | 8 |
| EC 1.13.11.2 | Catechol 2,3-dioxygenase | - | 9 | 533 |
| EC 1.13.12.2 | Lysine 2-monooxygenase | - | - | 1 |
| EC 1.13.99.3 | Tryptophan 2'-dioxygenase | Yes | - | - |
| EC 1.14.11.2 | Procollagen-proline dioxygenase | - | 16 | 89 |
| EC 1.14.12.3 | Benzene 1,2-dioxygenase | - | 6 | 9 |
| EC 1.14.13.2 | 4-hydroxybenzoate 3-monooxygenase | - | 3 | 198 |
| EC 1.14.14.3 | Alkanal monooxygenase (FMN-linked) | - | 19 | 96 |
| EC 1.14.15.2 | Camphor 1,2-monooxygenase | Yes | - | - |
| EC 1.14.16.2 | Tyrosine 3-monooxygenase | - | 10 | 45 |
| EC 1.14.17.3 | Peptidylglycine monooxygenase | - | 9 | 9 |
| EC 1.14.18.2 | CMP-N-acetylneuraminate monooxygenase | - | 11 | - |
| EC 1.14.19.2 | Acyl-[acyl-carrier-protein] desaturase | - | 17 | 114 |
| EC 1.14.21.2 | (S)-cheilanthifoline synthase | Yes | - | - |
| EC 1.14.99.2 | Kynurenine 7,8-hydroxylase | Yes | - | - |
| EC 1.15.1.2 | Superoxide reductase | - | 7 | 24 |
| EC 1.16.1.2 | Diferric-transferrin reductase | Yes | - | - |
| EC 1.17.1.2 | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | - | 434 | 653 |
| EC 1.17.3.2 | Xanthine oxidase | - | 6 | 37 |
| EC 1.17.4.2 | Ribonucleoside-triphosphate reductase | - | 18 | 654 |
| EC 1.17.99.2 | Ethylbenzene hydroxylase | Yes | - | - |
| EC 1.18.1.2 | Ferredoxin--NADP(+) reductase | - | 262 | 510 |
| EC 1.20.4.2 | Methylarsonate reductase | Yes | - | - |
| EC 1.21.3.2 | Columbamine oxidase | Yes | - | - |
| EC 1.21.4.2 | Glycine reductase | - | 22 | 88 |
| EC 1.97.1.2 | Pyrogallol hydroxytransferase | - | 2 | 10 |
| EC 2.1.1.2 | Guanidinoacetate N-methyltransferase | - | 8 | 6 |
| EC 2.1.2.2 | Phosphoribosylglycinamide formyltransferase | - | 24 | 805 |
| EC 2.1.3.2 | Aspartate carbamoyltransferase | - | 710 | 709 |
| EC 2.1.4.2 | Scyllo-inosamine-4-phosphate amidinotransferase | - | 4 | 7 |
| EC 2.2.1.2 | Transaldolase | - | 466 | 1074 |
| EC 2.3.1.2 | Imidazole N-acetyltransferase | Yes | - | - |
| EC 2.3.2.2 | Gamma-glutamyltransferase | - | 29 | 1048 |
| EC 2.3.3.2 | Decylcitrate synthase | Yes | - | - |
| EC 2.4.1.2 | Dextrin dextranase | - | - | 2 |
| EC 2.4.2.2 | Pyrimidine-nucleoside phosphorylase | - | 14 | 249 |
| EC 2.4.99.2 | Monosialoganglioside sialyltransferase | Yes | - | - |
| EC 2.5.1.2 | Thiamine pyridinylase | - | 1 | 25 |
| EC 2.6.1.2 | Alanine transaminase | - | 16 | 63 |
| EC 2.6.99.2 | Pyridoxine 5'-phosphate synthase | - | 259 | 160 |
| EC 2.7.1.2 | Glucokinase | - | 153 | 722 |
| EC 2.7.2.2 | Carbamate kinase | - | 48 | 523 |
| EC 2.7.3.2 | Creatine kinase | - | 34 | 14 |
| EC 2.7.4.2 | Phosphomevalonate kinase | - | 7 | 119 |
| EC 2.7.6.2 | Thiamine diphosphokinase | - | 7 | 236 |
| EC 2.7.7.2 | FAD synthetase | - | 24 | 659 |
| EC 2.7.8.2 | Diacylglycerol cholinephosphotransferase | - | 15 | 8 |
| EC 2.7.9.2 | Pyruvate, water dikinase | - | 16 | 618 |
| EC 2.7.10.2 | Non-specific protein-tyrosine kinase | - | 181 | 811 |
| EC 2.7.11.2 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase | - | 18 | 16 |
| EC 2.7.12.2 | Mitogen-activated protein kinase kinase | - | 58 | 63 |
| EC 2.7.13.2 | Protein-histidine tele-kinase | - | - | 1 |
| EC 2.8.1.2 | 3-mercaptopyruvate sulfurtransferase | - | 7 | 183 |
| EC 2.8.2.2 | Alcohol sulfotransferase | - | 9 | 78 |
| EC 2.8.3.2 | Oxalate CoA-transferase | Yes | - | - |
| EC 2.9.1.2 | O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase | - | 11 | - |
| EC 3.1.1.2 | Arylesterase | - | 13 | 175 |
| EC 3.1.2.2 | Palmitoyl-CoA hydrolase | - | 19 | 126 |
| EC 3.1.3.2 | Acid phosphatase | - | 106 | 662 |
| EC 3.1.4.2 | Glycerophosphocholine phosphodiesterase | - | - | 12 |
| EC 3.1.6.2 | Steryl-sulfatase | - | 3 | 8 |
| EC 3.1.7.2 | Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase | - | 11 | 370 |
| EC 3.1.8.2 | Diisopropyl-fluorophosphatase | - | 3 | - |
| EC 3.1.11.2 | Exodeoxyribonuclease III | - | 22 | 927 |
| EC 3.1.13.2 | Exoribonuclease H | Yes | - | - |
| EC 3.1.21.2 | Deoxyribonuclease IV (phage-T(4)-induced) | - | 270 | 301 |
| EC 3.1.22.4 | Crossover junction endodeoxyribonuclease | - | 557 | 655 |
| EC 3.1.26.3 | Ribonuclease III | - | 487 | 1087 |
| EC 3.1.27.2 | Bacillus subtilis ribonuclease | Yes | - | - |
| EC 3.1.30.2 | Serratia marcescens nuclease | - | 1 | 3 |
| EC 3.2.1.2 | Beta-amylase | - | 16 | 235 |
| EC 3.2.2.2 | Inosine nucleosidase | Yes | - | - |
| EC 3.3.1.2 | Adenosylmethionine hydrolase | - | 1 | 3 |
| EC 3.3.2.2 | Alkenylglycerophosphocholine hydrolase | Yes | - | - |
| EC 3.4.11.2 | Membrane alanyl aminopeptidase | - | 23 | 566 |
| EC 3.4.13.4 | Xaa-Arg dipeptidase | Yes | - | - |
| EC 3.4.14.2 | Dipeptidyl-peptidase II | - | 3 | 10 |
| EC 3.4.15.4 | Peptidyl-dipeptidase B | Yes | - | - |
| EC 3.4.16.4 | Serine-type D-Ala-D-Ala carboxypeptidase | - | 20 | 1766 |
| EC 3.4.17.2 | Carboxypeptidase B | - | 7 | 12 |
| EC 3.4.19.2 | Peptidyl-glycinamidase | Yes | - | - |
| EC 3.4.21.2 | Chymotrypsin C | - | 4 | - |
| EC 3.4.22.2 | Papain | - | 1 | 5 |
| EC 3.4.23.2 | Pepsin B | - | 2 | 2 |
| EC 3.4.24.3 | Microbial collagenase | - | 5 | 171 |
| EC 3.5.1.2 | Glutaminase | - | 182 | 445 |
| EC 3.5.2.2 | Dihydropyrimidinase | - | 11 | 269 |
| EC 3.5.3.2 | Guanidinoacetase | Yes | - | - |
| EC 3.5.4.2 | Adenine deaminase | - | 155 | 221 |
| EC 3.5.5.2 | Ricinine nitrilase | - | - | 3 |
| EC 3.5.99.2 | Thiaminase | - | 15 | 65 |
| EC 3.6.1.2 | Trimetaphosphatase | - | - | 2 |
| EC 3.6.2.2 | Phosphoadenylylsulfatase | Yes | - | - |
| EC 3.6.3.2 | Mg(2+)-importing ATPase | - | 4 | 269 |
| EC 3.6.4.2 | Dynein ATPase | - | - | 5 |
| EC 3.6.5.2 | Small monomeric GTPase | - | - | 5 |
| EC 3.7.1.2 | Fumarylacetoacetase | - | 6 | 219 |
| EC 3.8.1.2 | (S)-2-haloacid dehalogenase | - | 9 | 258 |
| EC 3.10.1.2 | Cyclamate sulfohydrolase | Yes | - | - |
| EC 3.11.1.2 | Phosphonoacetate hydrolase | - | - | 26 |
| EC 3.13.1.3 | 2'-hydroxybiphenyl-2-sulfinate desulfinase | - | 1 | 7 |
| EC 4.1.1.2 | Oxalate decarboxylase | - | 2 | 84 |
| EC 4.1.2.4 | Deoxyribose-phosphate aldolase | - | 333 | 699 |
| EC 4.1.3.3 | N-acetylneuraminate lyase | - | 84 | 165 |
| EC 4.1.99.2 | Tyrosine phenol-lyase | - | 8 | 20 |
| EC 4.2.1.2 | Fumarate hydratase | - | 108 | 1304 |
| EC 4.2.2.2 | Pectate lyase | - | 59 | 137 |
| EC 4.2.3.2 | Ethanolamine-phosphate phospho-lyase | Yes | - | - |
| EC 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | - | 593 | 2728 |
| EC 4.3.1.2 | Methylaspartate ammonia-lyase | - | 1 | 50 |
| EC 4.3.2.2 | Adenylosuccinate lyase | - | 46 | 1000 |
| EC 4.3.3.2 | Strictosidine synthase | - | 5 | 20 |
| EC 4.4.1.2 | Homocysteine desulfhydrase | - | 1 | 1 |
| EC 4.5.1.2 | 3-chloro-D-alanine dehydrochlorinase | Yes | - | - |
| EC 4.6.1.2 | Guanylate cyclase | - | 55 | 348 |
| EC 4.99.1.2 | Alkylmercury lyase | - | 10 | 16 |
| EC 5.1.1.2 | Methionine racemase | Yes | - | - |
| EC 5.1.2.2 | Mandelate racemase | - | 1 | 49 |
| EC 5.1.3.2 | UDP-glucose 4-epimerase | - | 57 | 1263 |
| EC 5.1.99.2 | 16-hydroxysteroid epimerase | Yes | - | - |
| EC 5.2.1.2 | Maleylacetoacetate isomerase | - | 11 | 257 |
| EC 5.3.1.3 | Arabinose isomerase | - | - | 1 |
| EC 5.3.2.2 | Oxaloacetate tautomerase | - | - | 3 |
| EC 5.3.3.2 | Isopentenyl-diphosphate Delta-isomerase | - | 272 | 489 |
| EC 5.3.99.3 | Prostaglandin-E synthase | - | 18 | 8 |
| EC 5.4.1.2 | Precorrin-8X methylmutase | - | 4 | 341 |
| EC 5.4.2.2 | Phosphoglucomutase | - | 63 | 609 |
| EC 5.4.3.3 | Beta-lysine 5,6-aminomutase | - | - | 20 |
| EC 5.4.4.2 | Isochorismate synthase | - | 16 | 433 |
| EC 5.4.99.2 | Methylmalonyl-CoA mutase | - | 18 | 657 |
| EC 5.5.1.2 | 3-carboxy-cis,cis-muconate cycloisomerase | - | 4 | 117 |
| EC 5.99.1.2 | DNA topoisomerase | - | 129 | 3565 |
| EC 6.1.1.2 | Tryptophan--tRNA ligase | - | 166 | 1398 |
| EC 6.2.1.2 | Butyrate--CoA ligase | - | 18 | 11 |
| EC 6.3.1.2 | Glutamate--ammonia ligase | - | 167 | 2685 |
| EC 6.3.2.2 | Glutamate--cysteine ligase | - | 139 | 670 |
| EC 6.3.3.2 | 5-formyltetrahydrofolate cyclo-ligase | - | 8 | 374 |
| EC 6.3.4.2 | CTP synthase | - | 691 | 859 |
| EC 6.3.5.2 | GMP synthase (glutamine-hydrolyzing) | - | 657 | 755 |
| EC 6.4.1.2 | Acetyl-CoA carboxylase | - | 1002 | 1868 |
| EC 6.5.1.2 | DNA ligase (NAD(+)) | - | 873 | 1033 |
| EC 6.6.1.2 | Cobaltochelatase | - | 4 | 526 |
| EC 1.1.1.3 | Homoserine dehydrogenase | - | 29 | 1951 |
| EC 1.1.2.4 | D-lactate dehydrogenase (cytochrome) | - | 7 | 342 |
| EC 1.1.3.5 | Hexose oxidase | Yes | - | - |
| EC 1.1.5.4 | Malate dehydrogenase (quinone) | - | 183 | - |
| EC 1.1.99.3 | Gluconate 2-dehydrogenase (acceptor) | - | 3 | 306 |
| EC 1.2.1.4 | Aldehyde dehydrogenase (NADP(+)) | - | 3 | 49 |
| EC 1.2.2.3 | Formate dehydrogenase (cytochrome-c-553) | Yes | - | - |
| EC 1.2.3.4 | Oxalate oxidase | - | 4 | 16 |
| EC 1.2.4.4 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) | - | 22 | 394 |
| EC 1.2.7.3 | 2-oxoglutarate synthase | - | 12 | 318 |
| EC 1.2.99.4 | Formaldehyde dismutase | - | - | 1 |
| EC 1.3.1.3 | Delta(4)-3-oxosteroid 5-beta-reductase | - | 4 | 2 |
| EC 1.3.3.4 | Protoporphyrinogen oxidase | - | 22 | 488 |
| EC 1.3.7.3 | Phycoerythrobilin:ferredoxin oxidoreductase | - | 20 | 5 |
| EC 1.3.99.3 | Acyl-CoA dehydrogenase | - | 9 | 417 |
| EC 1.4.1.3 | Glutamate dehydrogenase (NAD(P)(+)) | - | 37 | 223 |
| EC 1.4.3.3 | D-amino-acid oxidase | - | 15 | 55 |
| EC 1.4.99.3 | Amine dehydrogenase | - | 10 | 57 |
| EC 1.5.1.3 | Dihydrofolate reductase | - | 113 | 938 |
| EC 1.5.3.4 | N(6)-methyl-lysine oxidase | - | - | 1 |
| EC 1.5.99.3 | L-pipecolate dehydrogenase | - | - | 3 |
| EC 1.6.2.5 | NADPH--cytochrome-c2 reductase | - | - | 1 |
| EC 1.6.5.4 | Monodehydroascorbate reductase (NADH) | - | 11 | 19 |
| EC 1.6.99.5 | NADH dehydrogenase (quinone) | - | 2913 | 6045 |
| EC 1.7.1.3 | Nitrate reductase (NADPH) | - | 9 | 12 |
| EC 1.7.2.3 | Trimethylamine-N-oxide reductase (cytochrome c) | - | 17 | 181 |
| EC 1.7.3.3 | Urate oxidase | - | 28 | 218 |
| EC 1.7.99.6 | Nitrous-oxide reductase | - | 12 | 134 |
| EC 1.8.1.4 | Dihydrolipoyl dehydrogenase | - | 70 | 2977 |
| EC 1.8.3.3 | Glutathione oxidase | Yes | - | - |
| EC 1.8.4.3 | Glutathione--CoA-glutathione transhydrogenase | Yes | - | - |
| EC 1.8.99.3 | Hydrogensulfite reductase | - | 8 | 238 |
| EC 1.10.3.3 | L-ascorbate oxidase | - | 4 | 69 |
| EC 1.10.99.3 | Violaxanthin de-epoxidase | - | 4 | 1 |
| EC 1.11.1.3 | Fatty-acid peroxidase | Yes | - | - |
| EC 1.12.98.3 | Methanosarcina-phenazine hydrogenase | - | - | 6 |
| EC 1.13.11.3 | Protocatechuate 3,4-dioxygenase | - | 6 | 262 |
| EC 1.13.12.3 | Tryptophan 2-monooxygenase | - | 7 | 12 |
| EC 1.14.11.3 | Pyrimidine-deoxynucleoside 2'-dioxygenase | Yes | - | - |
| EC 1.14.12.4 | 3-hydroxy-2-methylpyridinecarboxylate dioxygenase | - | - | 1 |
| EC 1.14.13.3 | 4-hydroxyphenylacetate 3-monooxygenase | - | - | 135 |
| EC 1.14.14.5 | Alkanesulfonate monooxygenase | - | 78 | 385 |
| EC 1.14.15.3 | Alkane 1-monooxygenase | - | 13 | 201 |
| EC 1.14.16.3 | Anthranilate 3-monooxygenase | Yes | - | - |
| EC 1.14.17.4 | Aminocyclopropanecarboxylate oxidase | - | 27 | 12 |
| EC 1.14.19.3 | Linoleoyl-CoA desaturase | - | 1 | 47 |
| EC 1.14.21.3 | Berbamunine synthase | - | 1 | 2 |
| EC 1.14.99.3 | Heme oxygenase | - | 67 | 122 |
| EC 1.16.1.3 | Aquacobalamin reductase | - | 4 | 52 |
| EC 1.17.1.3 | Leucoanthocyanidin reductase | - | 1 | 11 |
| EC 1.17.3.3 | 6-hydroxynicotinate dehydrogenase | Yes | - | - |
| EC 1.17.99.3 | 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase | - | 4 | - |
| EC 1.18.1.3 | Ferredoxin--NAD(+) reductase | - | 28 | 162 |
| EC 1.21.3.3 | Reticuline oxidase | - | 2 | 25 |
| EC 1.21.4.3 | Sarcosine reductase | - | 17 | 29 |
| EC 1.97.1.3 | Sulfur reductase | Yes | - | - |
| EC 2.1.1.3 | Thetin--homocysteine S-methyltransferase | Yes | - | - |
| EC 2.1.2.3 | Phosphoribosylaminoimidazolecarboxamide formyltransferase | - | 469 | 600 |
| EC 2.1.3.3 | Ornithine carbamoyltransferase | - | 402 | 988 |
| EC 2.2.1.3 | Formaldehyde transketolase | - | 2 | 14 |
| EC 2.3.1.3 | Glucosamine N-acetyltransferase | Yes | - | - |
| EC 2.3.2.3 | Lysyltransferase | - | 13 | 3 |
| EC 2.3.3.3 | Citrate (Re)-synthase | - | - | 1 |
| EC 2.4.1.4 | Amylosucrase | - | 2 | 8 |
| EC 2.4.2.3 | Uridine phosphorylase | - | 12 | 270 |
| EC 2.4.99.3 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase | - | 3 | 1 |
| EC 2.5.1.3 | Thiamine-phosphate diphosphorylase | - | 336 | 1335 |
| EC 2.6.1.3 | Cysteine transaminase | - | - | 1 |
| EC 2.7.1.3 | Ketohexokinase | - | 4 | 18 |
| EC 2.7.2.3 | Phosphoglycerate kinase | - | 719 | 1900 |
| EC 2.7.3.3 | Arginine kinase | - | 20 | 37 |
| EC 2.7.4.3 | Adenylate kinase | - | 891 | 3338 |
| EC 2.7.6.3 | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase | - | 33 | 873 |
| EC 2.7.7.3 | Pantetheine-phosphate adenylyltransferase | - | 676 | 676 |
| EC 2.7.8.3 | Ceramide cholinephosphotransferase | Yes | - | - |
| EC 2.7.9.3 | Selenide, water dikinase | - | 101 | 301 |
| EC 2.7.11.3 | Dephospho-[reductase kinase] kinase | Yes | - | - |
| EC 2.7.13.3 | Histidine kinase | - | 457 | 41098 |
| EC 2.8.1.3 | Thiosulfate--thiol sulfurtransferase | Yes | - | - |
| EC 2.8.2.3 | Amine sulfotransferase | - | 2 | - |
| EC 2.8.3.3 | Malonate CoA-transferase | Yes | - | - |
| EC 3.1.1.3 | Triacylglycerol lipase | - | 146 | 857 |
| EC 3.1.2.3 | Succinyl-CoA hydrolase | Yes | - | - |
| EC 3.1.3.3 | Phosphoserine phosphatase | - | 28 | 803 |
| EC 3.1.4.3 | Phospholipase C | - | 21 | 352 |
| EC 3.1.6.3 | Glycosulfatase | Yes | - | - |
| EC 3.1.7.3 | Monoterpenyl-diphosphatase | - | - | 3 |
| EC 3.1.11.3 | Exodeoxyribonuclease (lambda-induced) | - | 4 | 66 |
| EC 3.1.13.3 | Oligonucleotidase | - | - | 11 |
| EC 3.1.21.3 | Type I site-specific deoxyribonuclease | - | 17 | 522 |
| EC 3.1.22.5 | Deoxyribonuclease X | Yes | - | - |
| EC 3.1.26.4 | Calf thymus ribonuclease H | - | 1318 | 574 |
| EC 3.1.27.3 | Ribonuclease T(1) | - | 16 | 42 |
| EC 3.2.1.3 | Glucan 1,4-alpha-glucosidase | - | 19 | 157 |
| EC 3.2.2.3 | Uridine nucleosidase | - | 1 | 11 |
| EC 3.3.2.4 | Trans-epoxysuccinate hydrolase | Yes | - | - |
| EC 3.4.11.3 | Cystinyl aminopeptidase | - | 3 | 1 |
| EC 3.4.13.5 | Xaa-methyl-His dipeptidase | - | - | 2 |
| EC 3.4.14.4 | Dipeptidyl-peptidase III | - | 8 | 19 |
| EC 3.4.15.5 | Peptidyl-dipeptidase Dcp | - | 2 | 263 |
| EC 3.4.16.5 | Carboxypeptidase C | - | 12 | 77 |
| EC 3.4.17.3 | Lysine carboxypeptidase | - | 4 | 8 |
| EC 3.4.19.3 | Pyroglutamyl-peptidase I | - | 147 | 256 |
| EC 3.4.21.3 | Metridin | Yes | - | - |
| EC 3.4.22.3 | Ficain | Yes | - | - |
| EC 3.4.23.3 | Gastricsin | - | 12 | 10 |
| EC 3.4.24.6 | Leucolysin | Yes | - | - |
| EC 3.5.1.3 | Omega-amidase | - | 9 | 2 |
| EC 3.5.2.3 | Dihydroorotase | - | 339 | 1678 |
| EC 3.5.3.3 | Creatinase | - | 3 | 24 |
| EC 3.5.4.3 | Guanine deaminase | - | 10 | 314 |
| EC 3.5.5.4 | Cyanoalanine nitrilase | - | 4 | 1 |
| EC 3.5.99.3 | Hydroxydechloroatrazine ethylaminohydrolase | - | 1 | 80 |
| EC 3.6.1.3 | Adenosinetriphosphatase | - | 28 | 434 |
| EC 3.6.3.3 | Cd(2+)-exporting ATPase | - | 15 | 242 |
| EC 3.6.4.3 | Microtubule-severing ATPase | - | 52 | 543 |
| EC 3.6.5.3 | Protein-synthesizing GTPase | - | - | 134 |
| EC 3.7.1.3 | Kynureninase | - | 82 | 144 |
| EC 3.8.1.3 | Haloacetate dehalogenase | - | 2 | 52 |
| EC 3.11.1.3 | Phosphonopyruvate hydrolase | - | - | 4 |
| EC 4.1.1.3 | Oxaloacetate decarboxylase | - | 66 | 802 |
| EC 4.1.2.5 | Threonine aldolase | - | 8 | 518 |
| EC 4.1.3.4 | Hydroxymethylglutaryl-CoA lyase | - | 13 | 330 |
| EC 4.1.99.3 | Deoxyribodipyrimidine photo-lyase | - | 18 | 739 |
| EC 4.2.1.3 | Aconitate hydratase | - | 59 | 1212 |
| EC 4.2.2.3 | Poly(beta-D-mannuronate) lyase | - | 24 | 30 |
| EC 4.2.3.3 | Methylglyoxal synthase | - | 204 | 323 |
| EC 4.2.99.20 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase | - | 61 | 51 |
| EC 4.3.1.3 | Histidine ammonia-lyase | - | 200 | 747 |
| EC 4.3.2.3 | Ureidoglycolate lyase | - | 8 | - |
| EC 4.3.3.3 | Deacetylisoipecoside synthase | - | - | 1 |
| EC 4.4.1.3 | Dimethylpropiothetin dethiomethylase | Yes | - | - |
| EC 4.5.1.3 | Dichloromethane dehalogenase | - | 2 | 15 |
| EC 4.6.1.6 | Cytidylate cyclase | Yes | - | - |
| EC 4.99.1.3 | Sirohydrochlorin cobaltochelatase | - | 23 | 125 |
| EC 5.1.1.3 | Glutamate racemase | - | 336 | 851 |
| EC 5.1.2.3 | 3-hydroxybutyryl-CoA epimerase | - | 200 | 239 |
| EC 5.1.3.3 | Aldose 1-epimerase | - | 18 | 521 |
| EC 5.1.99.3 | Allantoin racemase | Yes | - | - |
| EC 5.2.1.3 | Retinal isomerase | Yes | - | - |
| EC 5.3.1.4 | L-arabinose isomerase | - | 115 | 142 |
| EC 5.3.3.3 | Vinylacetyl-CoA Delta-isomerase | - | 1 | 55 |
| EC 5.3.99.4 | Prostaglandin-I synthase | - | 4 | 3 |
| EC 5.4.2.3 | Phosphoacetylglucosamine mutase | - | 9 | 46 |
| EC 5.4.3.4 | D-lysine 5,6-aminomutase | - | - | 16 |
| EC 5.4.4.3 | 3-(hydroxyamino)phenol mutase | Yes | - | - |
| EC 5.4.99.3 | 2-acetolactate mutase | Yes | - | - |
| EC 5.5.1.3 | Tetrahydroxypteridine cycloisomerase | Yes | - | - |
| EC 5.99.1.3 | DNA topoisomerase (ATP-hydrolyzing) | - | 279 | 4620 |
| EC 6.1.1.3 | Threonine--tRNA ligase | - | 698 | 686 |
| EC 6.2.1.3 | Long-chain-fatty-acid--CoA ligase | - | 50 | 1125 |
| EC 6.3.1.4 | Aspartate--ammonia ligase (ADP-forming) | Yes | - | - |
| EC 6.3.2.3 | Glutathione synthase | - | 78 | 683 |
| EC 6.3.3.3 | Dethiobiotin synthase | - | 252 | 696 |
| EC 6.3.4.3 | Formate--tetrahydrofolate ligase | - | 311 | 794 |
| EC 6.3.5.3 | Phosphoribosylformylglycinamidine synthase | - | 522 | 1391 |
| EC 6.4.1.3 | Propionyl-CoA carboxylase | - | 18 | 573 |
| EC 6.5.1.3 | RNA ligase (ATP) | - | 7 | 19 |
| EC 1.1.1.4 | (R,R)-butanediol dehydrogenase | - | 3 | 42 |
| EC 1.1.2.5 | D-lactate dehydrogenase (cytochrome c-553) | - | - | 5 |
| EC 1.1.3.6 | Cholesterol oxidase | - | 2 | 56 |
| EC 1.1.99.4 | Dehydrogluconate dehydrogenase | - | - | 6 |
| EC 1.2.1.5 | Aldehyde dehydrogenase (NAD(P)(+)) | - | 17 | 50 |
| EC 1.2.2.4 | Carbon-monoxide dehydrogenase (cytochrome b-561) | - | - | 11 |
| EC 1.2.3.5 | Glyoxylate oxidase | - | - | 2 |
| EC 1.2.7.4 | Carbon-monoxide dehydrogenase (ferredoxin) | - | 1 | 38 |
| EC 1.2.99.5 | Formylmethanofuran dehydrogenase | - | 12 | 216 |
| EC 1.3.1.4 | Cortisone alpha-reductase | Yes | - | - |
| EC 1.3.3.5 | Bilirubin oxidase | - | 1 | 55 |
| EC 1.3.7.4 | Phytochromobilin:ferredoxin oxidoreductase | - | 1 | 2 |
| EC 1.3.99.4 | 3-oxosteroid 1-dehydrogenase | - | 2 | 34 |
| EC 1.4.1.4 | Glutamate dehydrogenase (NADP(+)) | - | 31 | 438 |
| EC 1.4.3.4 | Monoamine oxidase | - | 23 | 90 |
| EC 1.4.99.4 | Aralkylamine dehydrogenase | - | 2 | 7 |
| EC 1.5.1.5 | Methylenetetrahydrofolate dehydrogenase (NADP(+)) | - | 808 | 376 |
| EC 1.5.3.5 | (S)-6-hydroxynicotine oxidase | - | - | 2 |
| EC 1.5.99.4 | Nicotine dehydrogenase | - | - | 7 |
| EC 1.6.2.6 | Leghemoglobin reductase | Yes | - | - |
| EC 1.6.5.5 | NADPH:quinone reductase | - | 13 | 603 |
| EC 1.6.99.6 | NADPH dehydrogenase (quinone) | - | - | 12 |
| EC 1.7.1.4 | Nitrite reductase (NAD(P)H) | - | 11 | 667 |
| EC 1.7.3.4 | Hydroxylamine oxidase | - | 1 | 18 |
| EC 1.7.99.7 | Nitric-oxide reductase | - | 2 | 171 |
| EC 1.8.1.5 | 2-oxopropyl-CoM reductase (carboxylating) | - | 1 | 1 |
| EC 1.8.3.4 | Methanethiol oxidase | - | - | 3 |
| EC 1.8.4.4 | Glutathione--cystine transhydrogenase | Yes | - | - |
| EC 1.10.3.4 | o-aminophenol oxidase | - | - | 3 |
| EC 1.11.1.5 | Cytochrome-c peroxidase | - | 18 | 442 |
| EC 1.13.11.4 | Gentisate 1,2-dioxygenase | - | - | 77 |
| EC 1.13.12.4 | Lactate 2-monooxygenase | - | 2 | 33 |
| EC 1.14.11.4 | Procollagen-lysine 5-dioxygenase | - | 15 | 9 |
| EC 1.14.12.5 | 5-pyridoxate dioxygenase | Yes | - | - |
| EC 1.14.13.4 | Melilotate 3-monooxygenase | Yes | - | - |
| EC 1.14.14.6 | Methanesulfonate monooxygenase | Yes | - | - |
| EC 1.14.15.4 | Steroid 11-beta-monooxygenase | - | 14 | 8 |
| EC 1.14.16.4 | Tryptophan 5-monooxygenase | - | 13 | 13 |
| EC 1.14.19.4 | Delta(8)-fatty-acid desaturase | Yes | - | - |
| EC 1.14.21.4 | Salutaridine synthase | - | - | 1 |
| EC 1.14.99.4 | Progesterone monooxygenase | - | - | 1 |
| EC 1.16.1.4 | Cob(II)alamin reductase | Yes | - | - |
| EC 1.17.1.4 | Xanthine dehydrogenase | - | 24 | 561 |
| EC 1.17.99.4 | Uracil/thymine dehydrogenase | Yes | - | - |
| EC 1.18.1.4 | Rubredoxin--NAD(P)(+) reductase | Yes | - | - |
| EC 1.21.3.4 | Sulochrin oxidase ((+)-bisdechlorogeodin-forming) | Yes | - | - |
| EC 1.21.4.4 | Betaine reductase | - | 17 | 26 |
| EC 1.97.1.4 | [Formate-C-acetyltransferase]-activating enzyme | - | 23 | 851 |
| EC 2.1.1.4 | Acetylserotonin O-methyltransferase | - | 4 | 13 |
| EC 2.1.2.4 | Glycine formimidoyltransferase | - | - | 4 |
| EC 2.1.3.5 | Oxamate carbamoyltransferase | Yes | - | - |
| EC 2.2.1.4 | Acetoin--ribose-5-phosphate transaldolase | Yes | - | - |
| EC 2.3.1.4 | Glucosamine-phosphate N-acetyltransferase | - | 9 | 19 |
| EC 2.3.2.4 | Gamma-glutamylcyclotransferase | - | 3 | - |
| EC 2.3.3.4 | Decylhomocitrate synthase | Yes | - | - |
| EC 2.4.1.5 | Dextransucrase | - | 8 | 74 |
| EC 2.4.2.4 | Thymidine phosphorylase | - | 170 | 306 |
| EC 2.4.99.4 | Beta-galactoside alpha-2,3-sialyltransferase | - | 9 | 8 |
| EC 2.5.1.4 | Adenosylmethionine cyclotransferase | - | - | 4 |
| EC 2.6.1.4 | Glycine transaminase | - | - | 2 |
| EC 2.7.1.4 | Fructokinase | - | 28 | 418 |
| EC 2.7.2.4 | Aspartate kinase | - | 44 | 2827 |
| EC 2.7.3.4 | Taurocyamine kinase | - | 1 | - |
| EC 2.7.4.4 | Nucleoside-phosphate kinase | Yes | - | - |
| EC 2.7.6.4 | Nucleotide diphosphokinase | Yes | - | - |
| EC 2.7.7.4 | Sulfate adenylyltransferase | - | 450 | 1271 |
| EC 2.7.8.4 | Serine-phosphoethanolamine synthase | Yes | - | - |
| EC 2.7.9.4 | Alpha-glucan, water dikinase | - | 4 | 16 |
| EC 2.7.11.4 | [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase | - | 4 | 7 |
| EC 2.8.1.4 | tRNA sulfurtransferase | - | 286 | 1 |
| EC 2.8.2.4 | Estrone sulfotransferase | - | 8 | 19 |
| EC 2.8.3.5 | 3-oxoacid CoA-transferase | - | 24 | 456 |
| EC 3.1.1.4 | Phospholipase A(2) | - | 379 | 228 |
| EC 3.1.2.4 | 3-hydroxyisobutyryl-CoA hydrolase | - | 11 | 30 |
| EC 3.1.3.4 | Phosphatidate phosphatase | - | 39 | 35 |
| EC 3.1.4.4 | Phospholipase D | - | 62 | 96 |
| EC 3.1.6.4 | N-acetylgalactosamine-6-sulfatase | - | 5 | 13 |
| EC 3.1.7.4 | Sclareol cyclase | Yes | - | - |
| EC 3.1.11.5 | Exodeoxyribonuclease V | - | 22 | 1269 |
| EC 3.1.13.4 | Poly(A)-specific ribonuclease | - | 78 | 47 |
| EC 3.1.21.4 | Type II site-specific deoxyribonuclease | - | 103 | 204 |
| EC 3.1.26.5 | Ribonuclease P | - | 690 | 527 |
| EC 3.1.27.4 | Ribonuclease U(2) | - | 1 | - |
| EC 3.2.1.4 | Cellulase | - | 175 | 834 |
| EC 3.2.2.4 | AMP nucleosidase | - | 2 | 285 |
| EC 3.3.2.5 | Alkenylglycerophosphoethanolamine hydrolase | Yes | - | - |
| EC 3.4.11.4 | Tripeptide aminopeptidase | - | 195 | 297 |
| EC 3.4.13.7 | Glu-Glu dipeptidase | Yes | - | - |
| EC 3.4.14.5 | Dipeptidyl-peptidase IV | - | 14 | 72 |
| EC 3.4.15.6 | Cyanophycinase | - | 6 | 10 |
| EC 3.4.16.6 | Carboxypeptidase D | - | 15 | 57 |
| EC 3.4.17.4 | Gly-Xaa carboxypeptidase | - | 1 | 13 |
| EC 3.4.19.5 | Beta-aspartyl-peptidase | - | 13 | 78 |
| EC 3.4.21.4 | Trypsin | - | 72 | 269 |
| EC 3.4.22.6 | Chymopapain | - | 1 | 8 |
| EC 3.4.23.4 | Chymosin | - | 4 | 14 |
| EC 3.4.24.7 | Interstitial collagenase | - | 10 | 12 |
| EC 3.5.1.4 | Amidase | - | 51 | 544 |
| EC 3.5.2.4 | Carboxymethylhydantoinase | - | - | 3 |
| EC 3.5.3.4 | Allantoicase | - | 42 | 144 |
| EC 3.5.4.4 | Adenosine deaminase | - | 216 | 681 |
| EC 3.5.5.5 | Arylacetonitrilase | - | - | 1 |
| EC 3.5.99.4 | N-isopropylammelide isopropylaminohydrolase | - | 1 | 103 |
| EC 3.6.1.5 | Apyrase | - | 16 | 67 |
| EC 3.6.3.4 | Cu(2+)-exporting ATPase | - | 27 | 811 |
| EC 3.6.4.4 | Plus-end-directed kinesin ATPase | - | - | 5 |
| EC 3.6.5.4 | Signal-recognition-particle GTPase | - | - | 10 |
| EC 3.7.1.4 | Phloretin hydrolase | Yes | - | - |
| EC 3.8.1.5 | Haloalkane dehalogenase | - | 29 | 87 |
| EC 4.1.1.4 | Acetoacetate decarboxylase | - | 33 | 66 |
| EC 4.1.2.8 | Indole-3-glycerol-phosphate lyase | - | 1 | 3 |
| EC 4.1.3.6 | Citrate (pro-3S)-lyase | - | 9 | 605 |
| EC 4.1.99.5 | Octadecanal decarbonylase | Yes | - | - |
| EC 4.2.1.4 | Citrate dehydratase | - | - | 1 |
| EC 4.2.2.5 | Chondroitin AC lyase | - | 1 | 6 |
| EC 4.2.3.4 | 3-dehydroquinate synthase | - | 526 | 656 |
| EC 4.3.1.4 | Formimidoyltetrahydrofolate cyclodeaminase | - | 6 | 51 |
| EC 4.3.2.4 | Purine imidazole-ring cyclase | Yes | - | - |
| EC 4.3.3.4 | Deacetylipecoside synthase | - | - | 7 |
| EC 4.4.1.4 | Alliin lyase | - | 4 | 28 |
| EC 4.5.1.4 | L-2-amino-4-chloropent-4-enoate dehydrochlorinase | Yes | - | - |
| EC 4.6.1.12 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | - | 525 | 846 |
| EC 4.99.1.4 | Sirohydrochlorin ferrochelatase | - | 145 | 151 |
| EC 5.1.1.4 | Proline racemase | - | 9 | 53 |
| EC 5.1.2.4 | Acetoin racemase | Yes | - | - |
| EC 5.1.3.4 | L-ribulose-5-phosphate 4-epimerase | - | 41 | 381 |
| EC 5.1.99.4 | Alpha-methylacyl-CoA racemase | - | 3 | 101 |
| EC 5.2.1.4 | Maleylpyruvate isomerase | - | 1 | 15 |
| EC 5.3.1.5 | Xylose isomerase | - | 197 | 478 |
| EC 5.3.3.4 | Muconolactone Delta-isomerase | - | 7 | 129 |
| EC 5.3.99.5 | Thromboxane-A synthase | - | 6 | 5 |
| EC 5.4.2.4 | Bisphosphoglycerate mutase | - | 18 | 9 |
| EC 5.4.3.5 | D-ornithine 4,5-aminomutase | Yes | - | - |
| EC 5.4.99.4 | 2-methyleneglutarate mutase | - | 1 | 3 |
| EC 5.5.1.4 | Inositol-3-phosphate synthase | - | 28 | 92 |
| EC 6.1.1.4 | Leucine--tRNA ligase | - | 761 | 610 |
| EC 6.2.1.4 | Succinate--CoA ligase (GDP-forming) | - | 28 | 52 |
| EC 6.3.1.5 | NAD(+) synthase | - | 290 | 478 |
| EC 6.3.2.4 | D-alanine--D-alanine ligase | - | 585 | 883 |
| EC 6.3.3.4 | (Carboxyethyl)arginine beta-lactam-synthase | - | 1 | 1 |
| EC 6.3.4.4 | Adenylosuccinate synthase | - | 697 | 1448 |
| EC 6.3.5.4 | Asparagine synthase (glutamine-hydrolyzing) | - | 32 | 871 |
| EC 6.4.1.4 | Methylcrotonoyl-CoA carboxylase | - | 14 | 241 |
| EC 6.5.1.4 | RNA-3'-phosphate cyclase | - | 91 | 112 |
| EC 1.1.1.5 | Acetoin dehydrogenase | - | 10 | 115 |
| EC 1.1.3.7 | Aryl-alcohol oxidase | - | - | 9 |
| EC 1.1.99.6 | D-2-hydroxy-acid dehydrogenase | - | - | 1 |
| EC 1.2.1.7 | Benzaldehyde dehydrogenase (NADP(+)) | Yes | - | - |
| EC 1.2.3.6 | Pyruvate oxidase (CoA-acetylating) | Yes | - | - |
| EC 1.2.7.5 | Aldehyde ferredoxin oxidoreductase | - | 5 | 290 |
| EC 1.2.99.6 | Carboxylate reductase | Yes | - | - |
| EC 1.3.1.5 | Cucurbitacin Delta(23)-reductase | Yes | - | - |
| EC 1.3.3.6 | Acyl-CoA oxidase | - | 35 | 43 |
| EC 1.3.7.5 | Phycocyanobilin:ferredoxin oxidoreductase | - | 25 | 22 |
| EC 1.3.99.5 | 3-oxo-5-alpha-steroid 4-dehydrogenase | - | 14 | 36 |
| EC 1.4.1.5 | L-amino-acid dehydrogenase | Yes | - | - |
| EC 1.4.3.5 | Pyridoxal 5'-phosphate synthase | - | 355 | 371 |
| EC 1.4.99.5 | Glycine dehydrogenase (cyanide-forming) | - | - | 3 |
| EC 1.5.1.6 | Formyltetrahydrofolate dehydrogenase | - | 8 | 4 |
| EC 1.5.3.6 | (R)-6-hydroxynicotine oxidase | - | 1 | 18 |
| EC 1.5.99.5 | Methylglutamate dehydrogenase | - | - | 1 |
| EC 1.6.5.6 | p-benzoquinone reductase (NADPH) | Yes | - | - |
| EC 1.7.1.5 | Hyponitrite reductase | Yes | - | - |
| EC 1.7.3.5 | 3-aci-nitropropanoate oxidase | - | - | 1 |
| EC 1.7.99.8 | Hydroxylamine oxidoreductase | Yes | - | - |
| EC 1.8.1.6 | Cystine reductase | - | - | 1 |
| EC 1.8.3.5 | Prenylcysteine oxidase | - | 6 | 3 |
| EC 1.8.4.7 | Enzyme-thiol transhydrogenase (glutathione-disulfide) | - | - | 6 |
| EC 1.10.3.5 | 3-hydroxyanthranilate oxidase | Yes | - | - |
| EC 1.11.1.6 | Catalase | - | 484 | 2280 |
| EC 1.13.11.5 | Homogentisate 1,2-dioxygenase | - | 83 | 202 |
| EC 1.13.12.5 | Renilla-luciferin 2-monooxygenase | - | 1 | 2 |
| EC 1.14.11.6 | Thymine dioxygenase | - | 14 | 2 |
| EC 1.14.12.7 | Phthalate 4,5-dioxygenase | - | 2 | 61 |
| EC 1.14.13.5 | Imidazoleacetate 4-monooxygenase | - | - | 1 |
| EC 1.14.14.7 | Tryptophan 7-halogenase | Yes | - | - |
| EC 1.14.15.5 | Corticosterone 18-monooxygenase | - | 5 | - |
| EC 1.14.16.5 | Glyceryl-ether monooxygenase | Yes | - | - |
| EC 1.14.19.5 | Delta(11)-fatty-acid desaturase | Yes | - | - |
| EC 1.14.21.5 | (S)-canadine synthase | - | - | 1 |
| EC 1.14.99.7 | Squalene monooxygenase | - | 14 | 24 |
| EC 1.16.1.5 | Aquacobalamin reductase (NADPH) | - | 1 | 4 |
| EC 1.17.1.5 | Nicotinate dehydrogenase | Yes | - | - |
| EC 1.17.99.5 | Bile-acid 7-alpha-dehydroxylase | - | 2 | 1 |
| EC 1.21.3.5 | Sulochrin oxidase ((-)-bisdechlorogeodin-forming) | Yes | - | - |
| EC 1.97.1.8 | Tetrachloroethene reductive dehalogenase | - | - | 5 |
| EC 2.1.1.5 | Betaine--homocysteine S-methyltransferase | - | 13 | 5 |
| EC 2.1.2.5 | Glutamate formimidoyltransferase | - | 6 | 51 |
| EC 2.1.3.6 | Putrescine carbamoyltransferase | - | 13 | 3 |
| EC 2.2.1.5 | 2-hydroxy-3-oxoadipate synthase | Yes | - | - |
| EC 2.3.1.5 | Arylamine N-acetyltransferase | - | 23 | 70 |
| EC 2.3.2.5 | Glutaminyl-peptide cyclotransferase | - | 5 | 36 |
| EC 2.3.3.5 | 2-methylcitrate synthase | - | 6 | 264 |
| EC 2.4.1.7 | Sucrose phosphorylase | - | 4 | 115 |
| EC 2.4.2.5 | Nucleoside ribosyltransferase | Yes | - | - |
| EC 2.4.99.5 | Galactosyldiacylglycerol alpha-2,3-sialyltransferase | Yes | - | - |
| EC 2.5.1.5 | Galactose-6-sulfurylase | - | - | 1 |
| EC 2.6.1.5 | Tyrosine transaminase | - | 8 | 50 |
| EC 2.7.1.5 | Rhamnulokinase | - | 65 | 94 |
| EC 2.7.2.6 | Formate kinase | Yes | - | - |
| EC 2.7.3.5 | Lombricine kinase | - | 2 | - |
| EC 2.7.4.6 | Nucleoside-diphosphate kinase | - | 737 | 1343 |
| EC 2.7.6.5 | GTP diphosphokinase | - | 30 | 1100 |
| EC 2.7.7.5 | Sulfate adenylyltransferase (ADP) | - | 1 | - |
| EC 2.7.8.5 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase | - | 60 | 920 |
| EC 2.7.9.5 | Phosphoglucan, water dikinase | - | 2 | 6 |
| EC 2.7.11.5 | [Isocitrate dehydrogenase (NADP(+))] kinase | - | 122 | 119 |
| EC 2.8.1.5 | Thiosulfate--dithiol sulfurtransferase | Yes | - | - |
| EC 2.8.2.5 | Chondroitin 4-sulfotransferase | - | 8 | 6 |
| EC 2.8.3.6 | 3-oxoadipate CoA-transferase | - | 7 | 296 |
| EC 3.1.1.5 | Lysophospholipase | - | 98 | 361 |
| EC 3.1.2.5 | Hydroxymethylglutaryl-CoA hydrolase | Yes | - | - |
| EC 3.1.3.5 | 5'-nucleotidase | - | 553 | 970 |
| EC 3.1.4.11 | Phosphoinositide phospholipase C | - | 64 | 43 |
| EC 3.1.6.6 | Choline-sulfatase | - | 1 | 68 |
| EC 3.1.7.5 | Geranylgeranyl diphosphate diphosphatase | Yes | - | - |
| EC 3.1.11.6 | Exodeoxyribonuclease VII | - | 849 | 1699 |
| EC 3.1.13.5 | Ribonuclease D | - | 2 | 67 |
| EC 3.1.21.5 | Type III site-specific deoxyribonuclease | - | 4 | 91 |
| EC 3.1.26.6 | Ribonuclease IV | Yes | - | - |
| EC 3.1.27.5 | Pancreatic ribonuclease | - | 110 | 7 |
| EC 3.2.1.6 | Endo-1,3(4)-beta-glucanase | - | 4 | 37 |
| EC 3.2.2.5 | NAD(+) nucleosidase | - | 10 | 11 |
| EC 3.3.2.6 | Leukotriene-A(4) hydrolase | - | 37 | 13 |
| EC 3.4.11.5 | Prolyl aminopeptidase | - | 36 | 788 |
| EC 3.4.13.9 | Xaa-Pro dipeptidase | - | 118 | 482 |
| EC 3.4.14.6 | Dipeptidyl-dipeptidase | Yes | - | - |
| EC 3.4.17.6 | Alanine carboxypeptidase | - | 1 | - |
| EC 3.4.19.6 | Pyroglutamyl-peptidase II | - | 3 | 1 |
| EC 3.4.21.5 | Thrombin | - | 7 | 4 |
| EC 3.4.22.7 | Asclepain | Yes | - | - |
| EC 3.4.23.5 | Cathepsin D | - | 11 | 28 |
| EC 3.4.24.11 | Neprilysin | - | 9 | 64 |
| EC 3.5.1.5 | Urease | - | 819 | 1318 |
| EC 3.5.2.5 | Allantoinase | - | 48 | 98 |
| EC 3.5.3.5 | Formimidoylaspartate deiminase | Yes | - | - |
| EC 3.5.4.5 | Cytidine deaminase | - | 125 | 621 |
| EC 3.5.5.6 | Bromoxynil nitrilase | - | - | 3 |
| EC 3.5.99.5 | 2-aminomuconate deaminase | - | 2 | 3 |
| EC 3.6.1.6 | Nucleoside-diphosphatase | - | 13 | 9 |
| EC 3.6.3.5 | Zn(2+)-exporting ATPase | - | 11 | 139 |
| EC 3.6.4.5 | Minus-end-directed kinesin ATPase | - | - | 2 |
| EC 3.6.5.5 | Dynamin GTPase | - | 24 | 24 |
| EC 3.7.1.5 | Acylpyruvate hydrolase | - | - | 15 |
| EC 3.8.1.6 | 4-chlorobenzoate dehalogenase | - | - | 1 |
| EC 4.1.1.5 | Acetolactate decarboxylase | - | 6 | 245 |
| EC 4.1.2.9 | Phosphoketolase | - | 2 | 161 |
| EC 4.1.3.13 | Oxalomalate lyase | Yes | - | - |
| EC 4.1.99.11 | Benzylsuccinate synthase | - | - | 2 |
| EC 4.2.1.5 | Arabinonate dehydratase | - | - | 2 |
| EC 4.2.2.6 | Oligogalacturonide lyase | - | 2 | 38 |
| EC 4.2.3.5 | Chorismate synthase | - | 700 | 1280 |
| EC 4.3.1.6 | Beta-alanyl-CoA ammonia-lyase | - | - | 2 |
| EC 4.3.2.5 | Peptidylamidoglycolate lyase | - | 10 | 2 |
| EC 4.4.1.5 | Lactoylglutathione lyase | - | 27 | 729 |
| EC 4.5.1.5 | S-carboxymethylcysteine synthase | Yes | - | - |
| EC 4.6.1.13 | Phosphatidylinositol diacylglycerol-lyase | - | 4 | 55 |
| EC 4.99.1.5 | Aliphatic aldoxime dehydratase | - | - | 2 |
| EC 5.1.1.5 | Lysine racemase | - | - | 1 |
| EC 5.1.2.5 | Tartrate epimerase | Yes | - | - |
| EC 5.1.3.5 | UDP-arabinose 4-epimerase | - | 7 | 4 |
| EC 5.1.99.5 | Hydantoin racemase | - | 1 | - |
| EC 5.2.1.5 | Linoleate isomerase | - | - | 3 |
| EC 5.3.1.6 | Ribose-5-phosphate isomerase | - | 466 | 998 |
| EC 5.3.3.5 | Cholestenol Delta-isomerase | - | 7 | 24 |
| EC 5.3.99.6 | Allene-oxide cyclase | - | 4 | 16 |
| EC 5.4.2.5 | Phosphoglucomutase (glucose-cofactor) | Yes | - | - |
| EC 5.4.3.6 | Tyrosine 2,3-aminomutase | - | - | 2 |
| EC 5.4.99.5 | Chorismate mutase | - | 21 | 909 |
| EC 5.5.1.5 | Carboxy-cis,cis-muconate cyclase | - | 1 | 16 |
| EC 6.1.1.5 | Isoleucine--tRNA ligase | - | 579 | 793 |
| EC 6.2.1.5 | Succinate--CoA ligase (ADP-forming) | - | 553 | 1919 |
| EC 6.3.1.6 | Glutamate--ethylamine ligase | Yes | - | - |
| EC 6.3.2.5 | Phosphopantothenate--cysteine ligase | - | 16 | 814 |
| EC 6.3.4.5 | Argininosuccinate synthase | - | 605 | 1141 |
| EC 6.3.5.5 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing) | - | 453 | 1436 |
| EC 6.4.1.5 | Geranoyl-CoA carboxylase | Yes | - | - |
| EC 1.1.1.6 | Glycerol dehydrogenase | - | 7 | 274 |
| EC 1.1.3.8 | L-gulonolactone oxidase | - | 5 | 49 |
| EC 1.1.99.7 | Lactate--malate transhydrogenase | Yes | - | - |
| EC 1.2.1.8 | Betaine-aldehyde dehydrogenase | - | 124 | 496 |
| EC 1.2.3.7 | Indole-3-acetaldehyde oxidase | Yes | - | - |
| EC 1.2.7.6 | Glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) | - | - | 6 |
| EC 1.2.99.7 | Aldehyde dehydrogenase (FAD-independent) | - | 1 | 9 |
| EC 1.3.1.6 | Fumarate reductase (NADH) | - | 2 | 39 |
| EC 1.3.3.7 | Dihydrouracil oxidase | Yes | - | - |
| EC 1.3.7.6 | Phycoerythrobilin synthase | - | 1 | - |
| EC 1.3.99.6 | 3-oxo-5-beta-steroid 4-dehydrogenase | - | - | 3 |
| EC 1.4.1.7 | Serine 2-dehydrogenase | Yes | - | - |
| EC 1.4.3.7 | D-glutamate oxidase | Yes | - | - |
| EC 1.5.1.7 | Saccharopine dehydrogenase (NAD(+), L-lysine-forming) | - | 8 | 167 |
| EC 1.5.3.7 | L-pipecolate oxidase | - | 6 | 1 |
| EC 1.5.99.6 | Spermidine dehydrogenase | Yes | - | - |
| EC 1.6.5.7 | 2-hydroxy-1,4-benzoquinone reductase | - | - | 2 |
| EC 1.7.1.6 | Azobenzene reductase | - | 1 | 15 |
| EC 1.8.1.7 | Glutathione-disulfide reductase | - | 32 | 533 |
| EC 1.8.4.8 | Phosphoadenylyl-sulfate reductase (thioredoxin) | - | 152 | 501 |
| EC 1.10.3.6 | Rifamycin-B oxidase | Yes | - | - |
| EC 1.11.1.7 | Peroxidase | - | 528 | 592 |
| EC 1.13.11.6 | 3-hydroxyanthranilate 3,4-dioxygenase | - | 56 | 39 |
| EC 1.13.12.6 | Cypridina-luciferin 2-monooxygenase | - | 1 | 2 |
| EC 1.14.11.7 | Procollagen-proline 3-dioxygenase | - | 10 | 3 |
| EC 1.14.12.8 | 4-sulfobenzoate 3,4-dioxygenase | Yes | - | - |
| EC 1.14.13.6 | Orcinol 2-monooxygenase | Yes | - | - |
| EC 1.14.15.6 | Cholesterol monooxygenase (side-chain-cleaving) | - | 13 | 5 |
| EC 1.14.16.6 | Mandelate 4-monooxygenase | Yes | - | - |
| EC 1.14.19.6 | Delta(12)-fatty-acid desaturase | Yes | - | - |
| EC 1.14.21.6 | Lathosterol oxidase | - | 5 | 10 |
| EC 1.14.99.9 | Steroid 17-alpha-monooxygenase | - | 24 | 4 |
| EC 1.16.1.6 | Cyanocobalamin reductase (cyanide-eliminating) | Yes | - | - |
| EC 1.21.3.6 | Aureusidin synthase | Yes | - | - |
| EC 1.97.1.9 | Selenate reductase | - | 3 | 20 |
| EC 2.1.1.6 | Catechol O-methyltransferase | - | 14 | 34 |
| EC 2.1.2.7 | D-alanine 2-hydroxymethyltransferase | - | - | 3 |
| EC 2.1.3.7 | 3-hydroxymethylcephem carbamoyltransferase | - | - | 1 |
| EC 2.2.1.6 | Acetolactate synthase | - | 73 | 3428 |
| EC 2.3.1.6 | Choline O-acetyltransferase | - | 8 | 21 |
| EC 2.3.2.6 | Leucyltransferase | - | 305 | 291 |
| EC 2.3.3.6 | 2-ethylmalate synthase | Yes | - | - |
| EC 2.4.1.8 | Maltose phosphorylase | - | - | 66 |
| EC 2.4.2.6 | Nucleoside deoxyribosyltransferase | - | 3 | 49 |
| EC 2.4.99.6 | N-acetyllactosaminide alpha-2,3-sialyltransferase | - | 4 | 9 |
| EC 2.5.1.6 | Methionine adenosyltransferase | - | 782 | 1732 |
| EC 2.6.1.6 | Leucine transaminase | Yes | - | - |
| EC 2.7.1.6 | Galactokinase | - | 145 | 389 |
| EC 2.7.2.7 | Butyrate kinase | - | 48 | 83 |
| EC 2.7.3.6 | Hypotaurocyamine kinase | Yes | - | - |
| EC 2.7.4.7 | Phosphomethylpyrimidine kinase | - | 26 | 978 |
| EC 2.7.7.6 | DNA-directed RNA polymerase | - | 3823 | 15824 |
| EC 2.7.8.6 | Undecaprenyl-phosphate galactose phosphotransferase | - | 1 | 512 |
| EC 2.7.11.6 | [Tyrosine 3-monooxygenase] kinase | Yes | - | - |
| EC 2.8.1.6 | Biotin synthase | - | 589 | 438 |
| EC 2.8.2.6 | Choline sulfotransferase | Yes | - | - |
| EC 2.8.3.7 | Succinate--citramalate CoA-transferase | Yes | - | - |
| EC 3.1.1.6 | Acetylesterase | - | - | 14 |
| EC 3.1.2.6 | Hydroxyacylglutathione hydrolase | - | 285 | 508 |
| EC 3.1.3.6 | 3'-nucleotidase | - | 65 | 174 |
| EC 3.1.4.12 | Sphingomyelin phosphodiesterase | - | 31 | 243 |
| EC 3.1.6.7 | Cellulose-polysulfatase | Yes | - | - |
| EC 3.1.21.6 | CC-preferring endodeoxyribonuclease | Yes | - | - |
| EC 3.1.26.7 | Ribonuclease P4 | Yes | - | - |
| EC 3.1.27.6 | Enterobacter ribonuclease | - | 1 | 72 |
| EC 3.2.1.7 | Inulinase | - | 2 | 9 |
| EC 3.2.2.6 | NAD(P)(+) nucleosidase | Yes | - | - |
| EC 3.3.2.7 | Hepoxilin-epoxide hydrolase | Yes | - | - |
| EC 3.4.11.6 | Aminopeptidase B | - | 3 | 4 |
| EC 3.4.13.12 | Met-Xaa dipeptidase | Yes | - | - |
| EC 3.4.14.9 | Tripeptidyl-peptidase I | - | 9 | 6 |
| EC 3.4.17.8 | Muramoylpentapeptide carboxypeptidase | - | - | 13 |
| EC 3.4.19.7 | N-formylmethionyl-peptidase | Yes | - | - |
| EC 3.4.21.6 | Coagulation factor Xa | - | 10 | 45 |
| EC 3.4.22.8 | Clostripain | - | 1 | 24 |
| EC 3.4.23.12 | Nepenthesin | - | 4 | - |
| EC 3.4.24.12 | Envelysin | - | 2 | 1 |
| EC 3.5.1.6 | Beta-ureidopropionase | - | 5 | 51 |
| EC 3.5.2.6 | Beta-lactamase | - | 134 | 771 |
| EC 3.5.3.6 | Arginine deiminase | - | 145 | 345 |
| EC 3.5.4.6 | AMP deaminase | - | 16 | 49 |
| EC 3.5.5.7 | Aliphatic nitrilase | - | 2 | 161 |
| EC 3.5.99.6 | Glucosamine-6-phosphate deaminase | - | 284 | 390 |
| EC 3.6.1.7 | Acylphosphatase | - | 270 | 522 |
| EC 3.6.3.6 | H(+)-exporting ATPase | - | 33 | 213 |
| EC 3.6.4.6 | Vesicle-fusing ATPase | - | 10 | 211 |
| EC 3.6.5.6 | Tubulin GTPase | Yes | - | - |
| EC 3.7.1.6 | Acetylpyruvate hydrolase | Yes | - | - |
| EC 3.8.1.7 | 4-chlorobenzoyl-CoA dehalogenase | - | - | 1 |
| EC 4.1.1.6 | Aconitate decarboxylase | - | - | 1 |
| EC 4.1.2.10 | Mandelonitrile lyase | - | 5 | 20 |
| EC 4.1.3.14 | 3-hydroxyaspartate aldolase | - | - | 1 |
| EC 4.1.99.12 | 3,4-dihydroxy-2-butanone-4-phosphate synthase | - | 242 | 39 |
| EC 4.2.1.6 | Galactonate dehydratase | - | 45 | 92 |
| EC 4.2.2.7 | Heparin lyase | - | 2 | 3 |
| EC 4.2.3.6 | Trichodiene synthase | - | 17 | 11 |
| EC 4.3.1.7 | Ethanolamine ammonia-lyase | - | 78 | 411 |
| EC 4.4.1.6 | S-alkylcysteine lyase | Yes | - | - |
| EC 4.6.1.14 | Glycosylphosphatidylinositol diacylglycerol-lyase | - | 2 | 14 |
| EC 4.99.1.6 | Indoleacetaldoxime dehydratase | Yes | - | - |
| EC 5.1.1.6 | Threonine racemase | Yes | - | - |
| EC 5.1.2.6 | Isocitrate epimerase | Yes | - | - |
| EC 5.1.3.6 | UDP-glucuronate 4-epimerase | - | 6 | 5 |
| EC 5.2.1.6 | Furylfuramide isomerase | Yes | - | - |
| EC 5.3.1.7 | Mannose isomerase | - | - | 4 |
| EC 5.3.3.6 | Methylitaconate Delta-isomerase | - | - | 51 |
| EC 5.3.99.7 | Styrene-oxide isomerase | Yes | - | - |
| EC 5.4.2.6 | Beta-phosphoglucomutase | - | 3 | 165 |
| EC 5.4.3.7 | Leucine 2,3-aminomutase | Yes | - | - |
| EC 5.4.99.7 | Lanosterol synthase | - | 9 | 14 |
| EC 5.5.1.6 | Chalcone isomerase | - | 49 | 7 |
| EC 6.1.1.6 | Lysine--tRNA ligase | - | 569 | 1960 |
| EC 6.2.1.6 | Glutarate--CoA ligase | - | - | 1 |
| EC 6.3.1.7 | 4-methyleneglutamate--ammonia ligase | Yes | - | - |
| EC 6.3.2.6 | Phosphoribosylaminoimidazolesuccinocarboxamide synthase | - | 539 | 1321 |
| EC 6.3.4.6 | Urea carboxylase | - | 3 | 101 |
| EC 6.3.5.6 | Asparaginyl-tRNA synthase (glutamine-hydrolyzing) | - | - | 5 |
| EC 6.4.1.6 | Acetone carboxylase | - | - | 25 |
| EC 1.1.1.7 | Propanediol-phosphate dehydrogenase | - | - | 1 |
| EC 1.1.3.9 | Galactose oxidase | - | 1 | 29 |
| EC 1.1.99.8 | Alcohol dehydrogenase (acceptor) | - | 12 | 98 |
| EC 1.2.1.9 | Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) | - | 9 | 167 |
| EC 1.2.3.8 | Pyridoxal oxidase | - | - | 4 |
| EC 1.2.7.7 | 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) | - | 20 | 60 |
| EC 1.3.1.7 | Meso-tartrate dehydrogenase | Yes | - | - |
| EC 1.3.3.8 | Tetrahydroberberine oxidase | Yes | - | - |
| EC 1.3.99.7 | Glutaryl-CoA dehydrogenase | - | 7 | 144 |
| EC 1.4.1.8 | Valine dehydrogenase (NADP(+)) | - | - | 3 |
| EC 1.4.3.8 | Ethanolamine oxidase | Yes | - | - |
| EC 1.5.1.8 | Saccharopine dehydrogenase (NADP(+), L-lysine-forming) | - | 5 | 12 |
| EC 1.5.3.10 | Dimethylglycine oxidase | - | - | 1 |
| EC 1.5.99.8 | Proline dehydrogenase | - | 22 | 401 |
| EC 1.7.1.7 | GMP reductase | - | 190 | 292 |
| EC 1.8.1.8 | Protein-disulfide reductase | - | 58 | 403 |
| EC 1.8.4.9 | Adenylyl-sulfate reductase (glutathione) | - | 3 | 13 |
| EC 1.11.1.8 | Iodide peroxidase | - | 5 | 10 |
| EC 1.13.11.8 | Protocatechuate 4,5-dioxygenase | - | 2 | 94 |
| EC 1.13.12.7 | Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) | - | 5 | 78 |
| EC 1.14.11.8 | Trimethyllysine dioxygenase | - | 7 | 3 |
| EC 1.14.12.9 | 4-chlorophenylacetate 3,4-dioxygenase | Yes | - | - |
| EC 1.14.13.7 | Phenol 2-monooxygenase | - | 11 | 83 |
| EC 1.14.15.7 | Choline monooxygenase | - | 5 | 12 |
| EC 1.14.21.7 | Biflaviolin synthase | Yes | - | - |
| EC 1.14.99.10 | Steroid 21-monooxygenase | - | 9 | 20 |
| EC 1.16.1.7 | Ferric-chelate reductase | - | 6 | 29 |
| EC 1.97.1.10 | Thyroxine 5'-deiodinase | - | 21 | - |
| EC 2.1.1.7 | Nicotinate N-methyltransferase | - | - | 1 |
| EC 2.1.2.8 | Deoxycytidylate 5-hydroxymethyltransferase | - | 3 | - |
| EC 2.1.3.8 | Lysine carbamoyltransferase | Yes | - | - |
| EC 2.2.1.7 | 1-deoxy-D-xylulose-5-phosphate synthase | - | 520 | 513 |
| EC 2.3.1.7 | Carnitine O-acetyltransferase | - | 8 | 32 |
| EC 2.3.2.7 | Aspartyltransferase | Yes | - | - |
| EC 2.3.3.7 | 3-ethylmalate synthase | Yes | - | - |
| EC 2.4.1.9 | Inulosucrase | - | - | 4 |
| EC 2.4.2.7 | Adenine phosphoribosyltransferase | - | 652 | 597 |
| EC 2.4.99.7 | Alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylgalactosaminide 6-alpha-sialyltransferase | - | 2 | 6 |
| EC 2.5.1.7 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | - | 563 | 809 |
| EC 2.6.1.7 | Kynurenine--oxoglutarate transaminase | - | 14 | 10 |
| EC 2.7.1.7 | Mannokinase | - | 1 | 2 |
| EC 2.7.2.8 | Acetylglutamate kinase | - | 590 | 497 |
| EC 2.7.3.7 | Opheline kinase | Yes | - | - |
| EC 2.7.4.8 | Guanylate kinase | - | 331 | 1011 |
| EC 2.7.7.7 | DNA-directed DNA polymerase | - | 1094 | 12059 |
| EC 2.7.8.7 | Holo-[acyl-carrier-protein] synthase | - | 569 | 487 |
| EC 2.7.11.7 | Myosin-heavy-chain kinase | - | 4 | 119 |
| EC 2.8.1.7 | Cysteine desulfurase | - | 292 | 2055 |
| EC 2.8.2.7 | UDP-N-acetylgalactosamine-4-sulfate sulfotransferase | Yes | - | - |
| EC 2.8.3.8 | Acetate CoA-transferase | - | 4 | 282 |
| EC 3.1.1.7 | Acetylcholinesterase | - | 24 | 155 |
| EC 3.1.2.7 | Glutathione thiolesterase | Yes | - | - |
| EC 3.1.3.7 | 3'(2'),5'-bisphosphate nucleotidase | - | 29 | 188 |
| EC 3.1.4.13 | Serine-ethanolaminephosphate phosphodiesterase | - | - | 10 |
| EC 3.1.6.8 | Cerebroside-sulfatase | - | 3 | 32 |
| EC 3.1.21.7 | Deoxyribonuclease V | - | 128 | 156 |
| EC 3.1.26.8 | Ribonuclease M5 | - | - | 48 |
| EC 3.1.27.7 | Ribonuclease F | Yes | - | - |
| EC 3.2.1.8 | Endo-1,4-beta-xylanase | - | 70 | 672 |
| EC 3.2.2.7 | Adenosine nucleosidase | Yes | - | - |
| EC 3.3.2.8 | Limonene-1,2-epoxide hydrolase | - | 1 | 9 |
| EC 3.4.11.7 | Glutamyl aminopeptidase | - | 6 | 127 |
| EC 3.4.13.17 | Non-stereospecific dipeptidase | Yes | - | - |
| EC 3.4.14.10 | Tripeptidyl-peptidase II | - | 6 | 6 |
| EC 3.4.17.10 | Carboxypeptidase E | - | 7 | 1 |
| EC 3.4.19.9 | Gamma-glutamyl hydrolase | - | 8 | 12 |
| EC 3.4.21.7 | Plasmin | - | 15 | 17 |
| EC 3.4.22.10 | Streptopain | - | 6 | 8 |
| EC 3.4.23.15 | Renin | - | 10 | 1 |
| EC 3.4.24.13 | IgA-specific metalloendopeptidase | - | 4 | 51 |
| EC 3.5.1.7 | Ureidosuccinase | Yes | - | - |
| EC 3.5.2.7 | Imidazolonepropionase | - | 275 | 285 |
| EC 3.5.3.7 | Guanidinobutyrase | - | 1 | 5 |
| EC 3.5.4.7 | ADP deaminase | Yes | - | - |
| EC 3.5.5.8 | Thiocyanate hydrolase | - | 3 | 15 |
| EC 3.5.99.7 | 1-aminocyclopropane-1-carboxylate deaminase | - | 53 | 158 |
| EC 3.6.1.8 | ATP diphosphatase | - | - | 2 |
| EC 3.6.3.7 | Na(+)-exporting ATPase | - | 3 | 5 |
| EC 3.6.4.7 | Peroxisome-assembly ATPase | Yes | - | - |
| EC 3.7.1.7 | Beta-diketone hydrolase | Yes | - | - |
| EC 3.8.1.8 | Atrazine chlorohydrolase | - | 1 | 31 |
| EC 4.1.1.7 | Benzoylformate decarboxylase | - | 2 | 59 |
| EC 4.1.2.11 | Hydroxymandelonitrile lyase | - | 1 | 4 |
| EC 4.1.3.16 | 4-hydroxy-2-oxoglutarate aldolase | - | 9 | 345 |
|